To reduce malaria morbidity and mortality in infants, the World Health Organization (WHO) recommends perennial malaria chemoprevention (PMC) with sulfadoxine-pyrimethamine in areas with moderate to high malaria transmission. However, a decade after WHO’s recommendation, only one country has adopted the strategy as national policy, and various barriers to PMC policy uptake remain. This study will assess PMC’s clinical effectiveness and operational feasibility in Nigeria. It aims to generate the necessary evidence to support the intervention’s uptake in the national health policy.
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